Prostatic Intraepithelial Neoplasia
MEDICAL CODING CLASSES IN KOCHI.
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Prostatic Intraepithelial Neoplasia
High-grade prostatic intraepithelial neoplasia (HGPIN) is generally accepted to be a precursor lesion of prostate cancer. The likely outcome of isolated low-grade PIN (LGPIN) lesions in prostate biopsies remains unclear. A follow-up study of 106 patients with LGPIN- and HGPIN lesions was performed.In a 2-y period, 207 men were diagnosed with isolated PIN on standard systematic sextant biopsy of the prostate. In total, 104 patients had LGPIN and 103 had HGPIN. No patients had ever received androgen deprivation therapy, chemotherapy or radiation therapy. In all, 106 patients who underwent repeat second or third sextant biopsies were analysed in the study; 30% of these patients received a selenium-vitamin E supplement for at least 6 months.These data are intriguing since the risk of finding prostate carcinoma on repeat sextant biopsy in the LGPIN group is 30%. This is higher than commonly reported. The importance of recognising and re-biopsying HGPIN was confirmed. If chemoprevention could be shown to be effective, it might be beneficial not only in HGPIN but also in LGPIN. The possible activity of chemopreventive agents and their combination with iso-flavonoids needs further investigation.
code classification- Diseases of the genitourinary system (Noo-n99)
- Diseases of male genital organs(N40-N53)
- Other and unspecified disorders of prostate(N42)
clinical informations
- PROSTATIC INTRAEPITHELIAL NEOPLASIA-. a premalignant change arising in the prostatic epithelium regarded as the most important and most likely precursor of prostatic adenocarcinoma. the neoplasia takes the form of an intra acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia which corresponds to nuclear grade 2 and 3 invasive prostate cancer.
Historically, there has been a great deal of confusion in the literature on prostatic premalignant changes because of the number of synonyms used to describe these changes. At a consensus conference in 1987, Dr. Gerald Murphy and colleagues endorsed the term “prostatic intraepithelial neoplasia” in keeping with the etymology of a similar condition found in the uterine cervix and in an effort to eliminate the confusion generated by the variety of terms used to describe the condition. Additionally, a grading system Figure1,Figure2, Figure3, Figure4 for PIN was established, ranging from 1 to 3. Currently, most pathologists do not identify grade 1 PIN, which has been shown to have little or no correlation with malignancy; pathologists do, however, combine grades 2 and 3 into one category (ie, HGPIN). According to several studies,5 well-trained pathologists have excellent interobserver agreement regarding the identification of HGPIN.
- PROSTATIC INTRAEPITHELIAL NEOPLASIA-. a premalignant change arising in the prostatic epithelium regarded as the most important and most likely precursor of prostatic adenocarcinoma. the neoplasia takes the form of an intra acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia which corresponds to nuclear grade 2 and 3 invasive prostate cancer.
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